期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 44, 页码 11895-11899出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406284
关键词
C-H activation; cyclization; indoles; palladium; reaction mechanisms
资金
- Science and Engineering Research Board, India [SR/S1/IC-24/2011]
- DST under Fast Track Scheme
- CSIR
- BRNS, India
A palladium-catalyzed dehydrogenative coupling between diarylamines and olefins has been discovered for the synthesis of substituted indoles. This intermolecular annulation approach incorporates readily available olefins for the first time and obviates the need of any additional directing group. An ortho palladation, olefin coordination, and beta-migratory insertion sequence has been proposed for the generation of olefinated intermediate, which is found to produce the expected indole moiety.
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