期刊
BEHAVIORAL NEUROSCIENCE
卷 121, 期 1, 页码 100-110出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.121.1.100
关键词
predator odor memory; basolateral amygdala; medial amygdala; unconditioned fear; conditioned fear
资金
- NIGMS NIH HHS [5 R25 GM56930-07] Funding Source: Medline
- NINDS NIH HHS [NS 39406] Funding Source: Medline
The basolateral (BLA) and medial nucleus (MeA) of the amygdala participate in the modulation of unconditioned fear induced by predator odor. However, the specific role of these amygdalar nuclei in predator odor-induced fear memory is not known. Therefore, fiber-sparing lesions or temporary inactivation of the BLA or MeA were made either prior to or after exposure to cat odor, and conditioned contextual fear behavior was examined the next day. BLA and MeA lesions produced significant reductions in cat odor-induced unconditioned and conditioned fear-related behavior. In addition, temporary pharmacological neural inactivation methods occurring after exposure to cat odor revealed subtle behavioral alterations indicative of a role of the BLA in fear memory consolidation but not memory retrieval. In contrast, the MeA appears to play a specific role in retrieval but not consolidation. Results show that the BLA participates in the conditioned and unconditioned cat odor stimulus association that underlies fear memory, underscore a novel role of the MeA in predator odor contextual conditioning, and demonstrate different roles of the BLA and MeA in modulating consolidation and retrieval of predator odor fear memory.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据