期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 4, 页码 1365-1368出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409693
关键词
biosensors; mechanical properties; nanoparticles; polymeric capsules
资金
- LOEWE
The physico-chemical properties of colloidal particles determine their uptake into cells. For a series of microparticles only one parameter, the mechanical stiffness, was varied, whereas other parameters such as size, shape, and charge were kept constant. The uptake was monitored in situ by analyzing individual particle trajectories including the progress of endocytosis, derived from local pH measurements around each particle. Evidence is presented that soft particles with low stiffness are transported faster to lysosomes than stiffer ones.
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