期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 22, 页码 5552-5555出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400944
关键词
boron; enantioselectivity; lithium; natural products; total synthesis
资金
- EPSRC
- GSK
- European Research Council (FP7, ERC grant) [246785]
- European Research Council (ERC) [246785] Funding Source: European Research Council (ERC)
- Engineering and Physical Sciences Research Council [EP/I038071/1] Funding Source: researchfish
- EPSRC [EP/I038071/1] Funding Source: UKRI
Lithiation/borylation methodology has been developed for the synthesis of acyclic quaternary-tertiary motifs with full control of relative and absolute stereochemistry, thus leading to all four possible isomers of a stereodiad. A novel intramolecular Zweifel-type olefination enabled acyclic stereocontrol to be transformed into cyclic stereocontrol. These key steps have been applied to the shortest enantioselective synthesis of (-)-filiformin to date (9 steps) with full stereocontrol.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据