期刊
IMMUNITY
卷 26, 期 2, 页码 205-213出版社
CELL PRESS
DOI: 10.1016/j.immuni.2007.01.009
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资金
- NIAID NIH HHS [U19 AI056362, R01 AI037526] Funding Source: Medline
- NIAMS NIH HHS [P50 AR054083] Funding Source: Medline
More than half of the nascent B cells in humans initially express autoreactive antibodies. However, most of these autoantibodies are removed from the repertoire at two checkpoints before maturation into naive B cells. A third checkpoint excludes remaining autoantibodies from the antigen -experienced IgM(+) memory B cell pool. Nevertheless, low-affinity self-reactive antibodies are frequently found in the serum of normal humans. To determine the source of these antibodies, we cloned and expressed antibodies from circulating human IgG(+) memory B cells. Surprisingly, we found that self-reactive antibodies including anti-nuclear antibodies were frequently expressed by IgG(+) memory B cells in healthy donors. Most of these antibodies were created de novo by somatic hypermutation during the transition between mature naive and IgG(+) memory B cells. We conclude that deregulation of self-reactive IgG(+) memory B cells may be associated with autoimmunity.
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