期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 52, 页码 14517-14521出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201407824
关键词
antibodies; arginine; glycopeptides; N-GlcNAcylation; solid-phase peptide synthesis
资金
- National Basic Research Program of China (973 program) [2013CB932800]
- National Major Project of China [2012ZX09J12108-01, 2012ZX09502-001-005]
- NSFC [91313301, 31470245]
As a unique and unappreciated protein posttranslational modification, arginine N-glycosylation was recently discovered to play an important role in the process that bacteria counteract host defenses. To provide chemical tools for further proteomic and biochemical studies on arginine N-glycosylation, we report the first general strategy for a rapid and cost-effective synthesis of glycopeptides carrying single or multiple arginine N-GlcNAcyl groups. These glycopeptides were successfully utilized to generate the first antibodies that can specifically recognize arginine N-GlcNAcylated peptides or proteins in a sequence-independent manner.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据