期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 38, 页码 10077-10081出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402305
关键词
cancer; cathepsin B; drug delivery; theranostics; tumor microenvironment
资金
- European Community [201279, 280761, 241919]
- Slovenian Research Agency [P1-0140, J3-4267]
- Deutsche Forschungsgemeinschaft
Cathepsin B (CtsB) is a lysosomal cysteine proteinase that is specifically translocated to the extracellular milieu during cancer progression. The development of a lipidated CtsB inhibitor incorporated into the envelope of a liposomal nanocarrier (LNC-NS-629) is described. Ex vivo and in vivo studies confirmed selective targeting and internalization of LNC-NS-629 by tumor and stromal cells, thus validating CtsB targeting as a highly promising approach to cancer diagnosis and treatment.
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