期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 17, 页码 4404-4407出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400037
关键词
gold; heterocycles; structure elucidation; sulfonamides; synthetic methods
资金
- NIHGMS [RO1 GM073932]
- National Science Foundation [DGE1106400]
- UC Berkeley
- National Institute of Health
The development of a gold(I)-catalyzed sulfination of aryl boronic acids is described. This transformation proceeds through an unprecedented mechanism which exploits the reactivity of gold(I)-heteroatom bonds to form sulfinate anions. Further in situ elaboration of the sulfinate intermediates leads to the corresponding sulfones and sulfonamides, two pharmacophores routinely encountered in drug discovery.
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