期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 25, 页码 6439-6442出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403754
关键词
alcohols; asymmetric catalysis; cycloaddition; palladium; synthetic methods
资金
- Innovation Program of Shanghai Municipal Education Commission [14ZZ023]
- National Key Basic Research Program of China [2013CB934101]
- Shanghai Pujiang Program [11PJD012]
- Shanghai Jiao Tong University
An efficient method for the enantioselective construction of tertiary vinylglycols through a palladium-catalyzed asymmetric decarboxylative cycloaddition of vinylethylene carbonates with formaldehyde was developed. By using a palladium complex generated in situ from [Pd-2(dba)(3)] CHCl3 and a phosphoramidite ligand as a catalyst under mild reaction conditions, the process allows conversion of racemic 4-substituted 4-vinyl-1,3-dioxolan-2-ones into the corresponding 1,3-dioxolanes, as methylene acetal protected tertiary vinylglycols, in high yields with good to excellent enantioselectivities.
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