期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 5, 页码 1218-1250出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201302823
关键词
crystallization; enantiomers; chromatography; hybrid processes; phase diagrams; racemization; separation methods
资金
- Deutsche Forschungsgemeinschaft [SE 586/15, SE 586/16, PAK 281]
- German Ministry of Education and Research (BMBF) [NMT/CT/03C0319]
- European Union [FP7-NMP2-SL2008-214129]
The provision of pure enantiomers is of increasing importance not only for the pharmaceutical industry but also for agrochemistry and biotechnology. In general, there are two rival approaches to provide pure enantiomers. The chiral approach is based on developing an asymmetric synthesis of just one of the enantiomers, while the racemic approach is based on separating mixtures of the two enantiomers. In the last few years remarkable progress has been achieved in the latter area. This Review focuses in particular on enantioselective crystallization processes and preparative chromatography, including hybrid processes and the incorporation of racemization steps. Several examples from our research are used for illustration purposes.
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