期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 10, 页码 3038-3042出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409815
关键词
acylsilanes; alkylation; asymmetric synthesis; copper catalysis; Grignard reactions
资金
- Netherlands Organization for Scientific Research (NWO-Vidi)
- China Scholarship Council (CSC)
- Ministry of Education, Culture and Science (Gravity program) [024.001.035]
The highly enantioselective addition of Grignard reagents to acylsilanes is catalyzed by copper diphosphine complexes. This transformation affords -silylated tertiary alcohols in up to 97% yield and 98:2 enantiomeric ratio. The competing Meerwein-Ponndorf-Verley reduction is suppressed by the use of a mixture of Lewis acid additives. The chiral catalyst can be recovered as a copper complex and used repeatedly without any loss of catalytic activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据