期刊
MINI-REVIEWS IN ORGANIC CHEMISTRY
卷 4, 期 1, 页码 1-14出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157019307779815875
关键词
cyclodextrins; neoglycoconjugates; glycoclusters; dendrimers; glycodendrimers; drug delivery; multivalent effect
This review concentrates on both the protein receptor and guest binding abilities of carbohydrate clusters based on a cyclodextrin core. The combination of both complexation abilities is the basis of one of the pursued approaches for developing site-specific drug delivery systems. Influence on the molecular recognition properties of the number of appended saccharides, the type of carbohydrate clustering and the type of the spacer arms, among other factors, are discussed.
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