期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 23, 页码 5760-5784出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201308235
关键词
chemical probes; chemical synthesis; guanidinium toxin; neurobiology; sodium ion channel
资金
- National Institutes of Health [R01 NS045684, R21 NS070064]
- Pfizer
- SiteOne Therapeutics
- Stanford Interdisciplinary Graduate Fellowship (SIGF)
The paralytic agent (+)-saxitoxin (STX), most commonly associated with oceanic red tides and shellfish poisoning, is a potent inhibitor of electrical conduction in cells. Its nefarious effects result from inhibition of voltage-gated sodium channels (Na(V)s), the obligatory proteins responsible for the initiation and propagation of action potentials. In the annals of ion channel research, the identification and characterization of Na(V)s trace to the availability of STX and an allied guanidinium derivative, tetrodotoxin. The mystique of STX is expressed in both its function and form, as this uniquely compact dication boasts more heteroatoms than carbon centers. This Review highlights both the chemistry and chemical biology of this fascinating natural product, and offers a perspective as to how molecular design and synthesis may be used to explore Na-V structure and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据