期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 6, 页码 1552-1555出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201308109
关键词
biosynthesis; fairy rings; microarrays; natural products; purine metabolism
资金
- MEXT
- Grants-in-Aid for Scientific Research [24102525, 26102736, 24102513, 26860013] Funding Source: KAKEN
Rings or arcs of fungus-stimulated plant growth occur worldwide; these are commonly referred to as fairy rings. In 2010, we discovered 2-azahypoxanthine (AHX), a compound responsible for the fairy-ring phenomenon caused by fungus; AHX stimulated the growth of all the plants tested. Herein, we reveal the isolation and structure determination of a common metabolite of AHX in plants, 2-aza-8-oxohypoxanthine (AOH). AHX is chemically synthesized from 5-aminoimidazole-4-carboxamide (AICA), and AHX can be converted into AOH by xanthine oxidase. AICA is one of the members of the purine metabolic pathway in animals, plants, and microorganisms. However, further metabolism of AICA remains elusive. Based on these results and facts, we hypothesized that plants themselves produce AHX and AOH through a pathway similar to the chemical synthesis. Herein, we demonstrate the existence of endogenous AHX and AOH and a novel purine pathway to produce them in plants.
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