期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 47, 页码 12849-12854出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406717
关键词
copper catalysis; isocyanides; isothioureas; Lewis acids; molecular sieves
资金
- University of Antwerp (BOF)
- Research Foundation-Flanders (FWO)
- Hercules Foundation
- The Netherlands Organization for Scientific Research (NWO)
- Innovative Medicines Initiative - European Union [115360]
Multiple applications of isothioureas as fine chemicals (or their precursors) are known, but a general sustainable method for their synthesis was hitherto unavailable. We report a novel general approach towards S-alkyl and S-aryl isothioureas through a copper(I)-catalyzed three-component reaction between amines, isocyanides, and thiosulfonates. The formal synthesis of a superpotent sweetener further illustrates the applicability of our method.
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