期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 41, 页码 10899-10903出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403186
关键词
agglutinins; biomembrane glycans; dendrimers; lectins; vesicles
资金
- National Science Foundation [DMR-1066116, DMR-1120901]
- P. Roy Vagelos Chair at the University of Pennsylvania
- EC (GLYCOPHARM) [317297]
- Natural Sciences and Engineering Research Council of Canada
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1066116] Funding Source: National Science Foundation
An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm. By simple injection of their THF solutions into water or buffer, all of the Janus compounds self-assembled into uniform, stable, and soft unilamellar vesicles, denoted glycodendrimersomes. The mixed constellation topology glycodendrimersomes were demonstrated to be most efficient in binding plant, bacterial, and human lectins. This evidence with biomedically relevant receptors offers a promising perspective for the application of such glycodendrimersomes in targeted drug delivery, vaccines, and other areas of nanomedicine.
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