期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 5, 页码 1646-1650出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201410471
关键词
C-H activation; cross-coupling; fluorine; heterocycles; palladium
资金
- National Institutes of Health [GM46059]
- JSPS
The synthesis of 3,3-difluoro-2-oxindoles through a robust and efficient palladium-catalyzed C-H difluoroalkylation is described. This process generates a broad range of difluorooxindoles from readily prepared starting materials. The use of BrettPhos as the ligand was crucial for high efficiency. Preliminary mechanistic studies suggest that oxidative addition is the rate-determining step for this process.
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