期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 9, 页码 2332-2338出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201310727
关键词
click chemistry; electrohydrodynamic co-jetting; microparticles; orthogonal chemistry; surface chemistry
资金
- Multidisciplinary University Research Initiative of the Department of Defense
- Army Research Office [W911NF-10-1-0518]
- DOD through idea award [W81XWH-11-1-0111]
- Tissue Engineering and Regenerative Medicine Training Grant [DE00007057-36]
- Scientific and Technical Research Council of Turkey (TUBITAK) [2219]
- Helmholtz Association through BIF program
- Helmholtz Association through Helmholtz-Portfolio Topic Technology and Medicine
Compared to two-dimensional substrates, only a few methodologies exist for the spatially controlled decoration of three-dimensional objects, such as microparticles. Combining electrohydrodynamic co-jetting with synthetic polymer chemistry, we were able to create two- and three-patch microparticles displaying chemically orthogonal anchor groups on three distinct surface patches of the same particle. This approach takes advantage of a combination of novel chemically orthogonal polylactide-based polymers and their processing by electrohydrodynamic co-jetting to yield unprecedented multifunctional microparticles. Several micropatterned particles were fabricated displaying orthogonal click functionalities. Specifically, we demonstrate novel two- and three-patch particles. Multi-patch particles are highly sought after for their potential to present multiple distinct ligands in a directional manner. This work clearly establishes a viable route towards orthogonal reaction strategies on multivalent micropatterned particles.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据