期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 13, 页码 3336-3341出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201311135
关键词
hybrid clusters; peptides; polyoxometalates; solid-phase synthesis; unnatural amino acids
资金
- EPSRC
- Royal Society/Wolfson foundation
- University of Glasgow
- EPSRC [EP/J015156/1] Funding Source: UKRI
General synthetic methods for the grafting of peptide chains onto polyoxometalate clusters by the use of general activated precursors have been developed. Using a solution-phase approach, pre-synthesized peptides can be grafted to a metal oxide cluster to produce hybrids of unprecedented scale (up to 30 residues). An adapted solid-phase method allows the incorporation of these clusters, which may be regarded as novel hybrid unnatural amino acids, during the peptide synthesis itself. These methods may open the way for the automated synthesis of peptides and perhaps even proteins that contain inorganic amino acids.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据