期刊
GROWTH HORMONE & IGF RESEARCH
卷 17, 期 1, 页码 10-18出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.ghir.2006.11.003
关键词
pregnancy associated plasma protein-A; insulin-like growth factor; IGF binding protein; pappalysin; protease
资金
- NHLBI NIH HHS [HL74871] Funding Source: Medline
Pregnancy-associated plasma protein-A (PAPP-A) was originally isolated in 1974, as one of four proteins of placental origin found in high concentrations in the blood of pregnant women. In the early 1990s several laboratories reported novel protease activity against insulin-like growth factor binding protein-4 (IGFBP-4) in media conditioned by several cell types. This activity was unique, as it appeared to require the presence of IGF to cleave IGFBP-4. In 1999, this IGF-dependent IGFBP-4 protease activity was isolated from human fibroblast conditioned media and identified as PAPP-A. Subsequently, PAPP-A was shown to be expressed by a variety of cell types, and thus no longer could be considered to be just pregnancy-associated. This review will describe what is currently known about the structure of PAPP-A and about its function as an IGFBP protease, with a focus on new insights obtained through study of a PAPP-A knock-out mouse model and on potential clinical applications. (c) 2006 Elsevier Ltd. All rights reserved.
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