期刊
EUROPEAN JOURNAL OF IMMUNOLOGY
卷 37, 期 2, 页码 540-548出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/eji.200636191
关键词
chronic arthritis; eosinophils; IL-5; Th2; Th1
类别
Eosinophilia is a characteristic feature of many inflammatory diseases including inflammatory bowel disease and asthma. It also occurs in a subtype of rheumatoid arthritis but the role of eosinophils has been unclear and animal models have been lacking. Here, we introduce a new mouse model to study the role of eosinophilia in arthritis. Intraperitoneal injection of type II collagen alone, without any adjuvant, was sufficient to induce chronic arthritis in a mouse with transgenic T cells specific for type II collagen. The arthritis was accompanied by infiltration of eosinophils into the synovial tissue and the disease could be blocked with neutralizing anti-IL-5 antibodies. To our knowledge, this is the first description of an eosinophilic disease form of destructive arthritis.
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