期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 18, 期 1, 页码 67-76出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.01.001
关键词
second heart field; anterior heart field; Isl1; MEF2C; transcription factor
资金
- NHLBI NIH HHS [HL64658, R01 HL064658] Funding Source: Medline
- NIAMS NIH HHS [R01 AR052130, AR52130] Funding Source: Medline
The heart is the first organ to form and function during vertebrate development and is absolutely essential for life. The left ventricle is derived from the classical primary or first heart field (FHF), while the right ventricle and outflow tract are derived front a distinct second heart field (SHF). The recent discovery of the SHF has raised several fundamental and important questions about how the two heart fields are integrated into a single organ and whether unique molecular programs control the development of the two heart fields. This review briefly highlights the contributions of the SHF to the developing and mature heart and then focuses primarily on our Current understanding of the transcriptional pathways that function in the development of the SHF and its derivatives. (c) 2007 Elsevier Ltd. All rights reserved.
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