期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 18, 页码 4597-4602出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309998
关键词
conducting polymers; electrical stimulation; EpCAM; HeLa cells; MCF7 cells
资金
- National Cancer Center grant from the Republic of Korea [1310180-1]
- Korea Health Promotion Institute [1310180-1] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The specific capture and remotely controlled release of the EpCAM-positive cancer cells from biotin-doped polypyrrole (Ppy) films in response to an electrical potential is presented. As Ppy allows the direct incorporation of biotin molecules during the electrochemical process, densely packed biotin molecules can serve as the binding sites for streptavidin-tagged biomolecular complexes. This study demonstrates not only the enhanced capture and enrichment of EpCAM-positive cancer cells but also on-demand release of the viable cells from conductive Ppy in an electrical-potential-dependent way. This novel approach is of great importance in a diverse range of applications, and in particular in cancer diagnostics and screening.
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