期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 51, 页码 14245-14249出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406843
关键词
antigen presentation; antitumor vaccines; glycopeptides; T-cell epitopes; tumor cell recognition
资金
- Fonds der Chemischen Industrie
- Deutsche Forschungsgemeinschaft [SFB 1066]
In a new concept of fully synthetic vaccines, the role of T-helper cells is emphasized. Here, a synthetic antitumor vaccine consisting of a diglycosylated tumor-associated MUC1 glycopeptide as the B-cell epitope was covalently cross-linked with three different T-helper-cell epitopes via squaric acid ligation of two linear (glyco) peptides. In mice this four-component vaccine administered without external immunestimulating promoters elicit titers of MUC1-specific antibodies that were about eight times higher than those induced by a vaccine containing only one T-helper-cell epitope. The promising results indicate that multiple activation of different T-helper cells is useful for applications in which increased immunogenicity is required. In personalized medicine, in particular, this flexible construction of a vaccine can serve as a role model, for example, when T-helper-cell epitopes are needed that match human leukocyte antigens (HLA) in different patients.
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