期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 13, 页码 3392-3395出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201310019
关键词
antimicrobial agents; diarylethenes; gramicidinS; peptidomimetics; photochemistry
资金
- KHYS
- Enamine Ltd.
Photobiological processes in nature are usually triggered by nonpeptidic chromophores or by modified side chains. A system is presented in which the polypeptide backbone itself can be conformationally switched by light. An amino acid analogue was designed and synthesized based on a reversibly photoisomerizable diarylethene scaffold. This analogue was incorporated into the cyclic backbone of the antimicrobial peptide gramicidinS at several sites. The biological activity of the resulting peptidomimetics could then be effectively controlled by ultraviolet/visible light within strictly defined spatial and temporal limits.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据