期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 19, 页码 4812-4815出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402144
关键词
antitumor agents; chemoembolization; drug delivery; iron oxide; liver cancer
资金
- Innovation Technology Fund [ITS/066/09]
- RGC-General Research Fund [201213]
A hybrid composite made up of superparamagnetic iron oxide nanoshells encapsulating the anticancer drug doxorubicin and bound together by poly(vinyl alcohol) was developed. Transcatheter arterial delivery in an invivo liver tumor model led to embolization of the liver tumor blood vessels. Embolization was followed by disassembly of the composite. The nanoshells were then able to pass through the leaky tumor vasculature into the tumor tissue, thereby leading to slow and sustained release of the drug. As well as being relatively noncytotoxic, the composite was responsive to magnetic resonance imaging, thus making it a potentially useful theranostic agent.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据