期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 25, 页码 6482-6486出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402301
关键词
amination reactions; amines; N-heterocyclic carbenes; homogeneous catalysis; palladium
资金
- CNRS
- Chinese Scholarship Council (CSC)
A challenging synthetic modification of PEPPSI-type palladium pre-catalysts consisting of a stepwise incorporation of one and two amino groups onto the NHC skeleton was seen to exert a sequential enhancement of the electronic donor properties. This appears to be positively correlated with the catalytic performances of the corresponding complexes in the Buchwald-Hartwig amination. This is illustrated, for example, by the quantitative amination of 4-chloroanisole by morpholine within 2 h at 25 degrees C with a 2 mol% catalyst/ substrate ratio or by a significant reduction of catalytic loading (down to 0.005 mol%) for the coupling of aryl chlorides with anilines (max TON: 19600).
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