期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 41, 页码 10970-10974出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406815
关键词
cascade reactions; decalin; natural products; polyketides; total synthesis
资金
- Cancer Prevention & Research Institute of Texas (CPRIT)
- National Institutes of Health (USA) [AI0055475]
- National Science Foundation
- Rice University
- Bristol-Myers Squibb
- Marie-Curie International Outgoing Fellowship, European Commission
The total synthesis of cytotoxic polyketides myceliothermophins E (1), C (2), and D (3) through a cascade-based cyclization to form the trans-fused decalin system is described. The convergent synthesis delivered all three natural products through late-stage divergence and facilitated unambiguous C21 structural assignments for 2 and 3 through X-ray crystallographic analysis, which revealed an interesting dimeric structure between its enantiomeric forms.
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