期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 47, 页码 12941-12945出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201404668
关键词
inhibitors; NMR spectroscopy; nuclear spin hyperpolarization; PHIP; signal enhancement
资金
- Deutsche Forschungsgemeinschaft [Bu-911-22-1]
A series of novel bioactive derivatives of the sunflower trypsin inhibitor-1 (SFTI-1) suitable for hyperpolarization by parahydrogen-induced polarization (PHIP) was developed. The PHIP activity was achieved by labeling with L-propargylglycine, O-propargyl-l-tyrosine, or 4-pentynoic acid. H-1 NMR signal enhancements (SE) of up to a factor of 70 were achieved in aqueous solution. We found that an isolated spatial location of the triple bond within the respective label and its accessibility for the hydrogenation catalyst are essential factors for the degree of signal enhancement.
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