期刊
INTERNATIONAL JOURNAL OF PHARMACEUTICS
卷 329, 期 1-2, 页码 173-181出版社
ELSEVIER
DOI: 10.1016/j.ijpharm.2006.08.022
关键词
absorption enhancer; nanoemulsion; poloxamer
On the basis of Pluronic (R) P104 as primary emulsifier and Lauroglycol (R) d90 as amphiphilic oil phase, two nanoemulsion systems were developed with Pluronic (R) L62 or L81 as secondary emulsifiers. The possible nanoemulsion region of combinations of these excipients was described in ternary phase diagrams. Three formulations were selected from the nanoemulsion region and their potential impact on oral absorption was examined in the Caco-2 monolayer model of the small intestine. The apparent pen-neability of the BCS class III compound Atenolol was enhanced 2.5-fold, of BCS class 11 compound Danazol 3.2-fold and of BCS class I compound Metoprolol 1.4-fold. The three formulations were very well tolerated by the Caco-2 cells, which was confirmed by TEER measurements, a MTT test and a LDH release test. (c) 2006 Elsevier B.V. All rights reserved.
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