期刊
FEBS LETTERS
卷 581, 期 3, 页码 479-482出版社
WILEY
DOI: 10.1016/j.febslet.2007.01.010
关键词
UCP; mitochondria; polymorphism; proteolysis
This study focused on the stability of UCP2 (uncoupling protein 2), a mitochondrial carrier located in the inner membrane of mitochondrion. UCP2 is very unstable, with a half-life close to 30 min, compared to 30 It for its homologue UCP1, a difference that may highlight different physiological functions. Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation. We show that a mutation in UCP2 shown to modify its activity, actually decreases its stability. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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