期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 20, 页码 5210-5213出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201400627
关键词
anodic biaryl synthesis; CC coupling; green chemistry; oxidative coupling; phenol cross-coupling
The direct oxidative cross-coupling of phenols is a very challenging transformation, as homo-coupling is usually strongly preferred. Electrochemical methods circumvent the use of oxidizing reagents or metal catalysts and are therefore highly attractive. Employing electrolytes with a high capacity for hydrogen bonding, such as methanol with formic acid or 1,1,1,3,3,3-hexafluoro-2-propanol, a direct electrolysis in an undivided cell provides mixed 2,2-biphenols with high selectivity. This mild method tolerates a variety of moieties, for example, tert-butyl groups, which are not compatible with other strong electrophilic media but vital for later catalytic applications of the formed products.
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