期刊
EMBO JOURNAL
卷 26, 期 3, 页码 752-763出版社
WILEY
DOI: 10.1038/sj.emboj.7601541
关键词
cell cycle; c-Myc; chromatin remodeling; E2F; SWI/SNF
资金
- NCI NIH HHS [R24 CA088261, 1R24CA88261] Funding Source: Medline
- NIGMS NIH HHS [R01GM073257, R01 GM073257] Funding Source: Medline
The mammalian SWI/SNF chromatin remodeling complex is becoming increasingly recognized for its role in tumor suppression, based on its ability to regulate accessibility of proliferation-associated genes to transcription factors. However, understanding the biological role of the complex is complicated because the same complex seemingly plays both positive and negative roles in gene expression. Work described here reveals that a choice between two independently encoded, closely related variants of a major subunit of the ARID protein family determines whether the SWI/SNF complex forms further associations with activator versus repressor complexes. The choice distinguishes assemblies with opposite effects on cell-cycle activity. The specific complexes control access of factors such as E2F1, Tip60, and HDAC1/2/3 to the promoters of various cell-cycle-specific genes, with c-Myc emerging as a particularly critical target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据