期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 36, 页码 9622-9626出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201405200
关键词
asymmetric synthesis; cooperative catalysis; beta-lactones; N-heterocyclic carbenes; organo catalysis
资金
- NRW Graduate School of Chemistry
- [SFB 858]
The reaction of enals with beta-diketones, beta-ketoesters, and malonates bearing a beta-oxyalkyl substituent at the alpha-position by oxidative NHC catalysis to provide highly substituted beta-lactones is described. Reactions occur with excellent diastereo- and enantioselectivity. The organo cascade comprises two C-C bond formations and one C-O bond formation. Up to four contiguous stereogenic centers including two fully substituted stereocenters are formed in the cascade.
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