期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 32, 页码 8416-8420出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201405014
关键词
CO2 conversion; gas/liquid continuous flow; Grignard reactions; ketones; organic lithium reactivity
资金
- Novartis-MIT Center for Continuous Manufacturing
- MIT Skoltech program
We describe an efficient continuous flow synthesis of ketones from CO2 and organolithium or Grignard reagents that exhibits significant advantages over conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproducts. We observed an unprecedented solvent-dependence of the organolithium reactivity, the key factor in governing selectivity during the flow process. A facile, telescoped three-step-one-flow process for the preparation of ketones in a modular fashion through the in-line generation of organometallic reagents is also established.
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