期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 54, 期 2, 页码 638-642出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201409705
关键词
alkenes; fluorination; fluorine; ketones; silver
资金
- National Basic Research Program of China [2015CB931900, 2012CB215500]
- NNSFC [21421002, 21372246, 21302206]
- Shanghai QMX program [13QH1402400]
- Chinese Academy of Sciences
A AgF-mediated fluorination with a concomitant cross-coupling between a gem-difluoroolefin and a non-fluorinated olefin is reported. This highly efficient method provides facile access to both -CF3 alkenes and -CF3 ketones, which otherwise remain challenging to be directly prepared. The application of this method is further demonstrated by the synthesis of bioactive isoxazoline derivatives. This approach represents a conceptually novel route to trifluoromethylated compounds that combines the insitu generation of the CF3 moiety and a CH functionalization in a single reaction system.
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