4.8 Article

Chemoselective Catalytic Conjugate Addition of Alcohols over Amines

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 6, 页码 1611-1615

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201309755

关键词

amino alcohols; chemoselective catalysis; cooperative effects; proton transfer; synthetic methods

资金

  1. MEXT
  2. CREST from JST
  3. Uehara Memorial Foundation
  4. Takeda Science Foundation
  5. Kyushu University Interdisciplinary Programs in Education and Projects in Research Development
  6. Grants-in-Aid for Scientific Research [24106733, 24890158] Funding Source: KAKEN

向作者/读者索取更多资源

A highly chemoselective conjugate addition of alcohols in the presence of amines is described. The cooperative nature of the catalyst enabled chemoselective activation of alcohols over amines, allowing the conjugate addition to soft Lewis basic ,-unsaturated nitriles. Divergent transformation of the nitrile functionality highlights the utility of the present catalysis.

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