期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 47, 页码 12765-12770出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201406852
关键词
imprinting; molecular recognition; polymers; protein mimics
资金
- PRESTO (Creation of Innovative Technology by Integration of Nanotechnology with Information, Biological, and Environmental Technologies), Japan Science and Technology Agency (JST)
Conjugated-protein mimics were obtained using a new molecular imprinting strategy combined with post-imprinting modifications. An antibiotic was employed as a model template molecule, and a polymerizable template molecule was designed, which was composed of the antibiotic and two different prosthetic groups attached through a disulfide bond and Schiff base formation. After co-polymerization with a cross-linker, the template molecule was removed together with the prosthetic groups, yielding the apo-type scaffold. Through conjugation of the two different prosthetic groups at pre-determined positions within the apo-type scaffold, the apo cavity was transformed into a functionalized holo cavity, which enables the on/off switching of the molecular recognition ability, signal transduction activity for binding events, and photoresponsive activity.
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