期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 9, 页码 2371-2375出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201308920
关键词
DNA hybrids; drug delivery; mesoporous materials; microRNA; nanocarriers
资金
- National Basic Research Program of China [2011CB933502]
- National Natural Science Foundation of China [21020102038, 21335004, 21205060, 21121091]
- State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1203]
The design of an ideal drug delivery system with targeted recognition and zero premature release, especially controlled and specific release that is triggered by an exclusive endogenous stimulus, is a great challenge. A traceable and aptamer-targeted drug nanocarrier has now been developed; the nanocarrier was obtained by capping mesoporous silica-coated quantum dots with a programmable DNA hybrid, and the drug release was controlled by microRNA. Once the nanocarriers had been delivered into HeLa cells by aptamer-mediated recognition and endocytosis, the overexpressed endogenous miR-21 served as an exclusive key to unlock the nanocarriers by competitive hybridization with the DNA hybrid, which led to a sustained lethality of the HeLa cells. If microRNA that is exclusively expressed in specific pathological cell was screened, a combination of chemotherapy and gene therapy should pave the way for a targeted and personalized treatment of human diseases.
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