期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 29, 页码 7594-7598出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201403446
关键词
annulation; asymmetric synthesis; cooperative catalysis; N-heterocyclic carbene; synthetic methods
资金
- NIH [R01-GM073072]
The highly enantioselective NHC-catalyzed [3+2] annulation reaction with alpha,beta-alkynals and alpha-ketoesters has been developed. A new mode of cooperative catalysis involving the combination of a chiral Bronsted acid and a C-1-symmetric biaryl saturated-imidazolium precatalyst was required to generate the desired gamma-crotonolactones in high yields and levels of enantioselectivity.
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