期刊
FORENSIC SCIENCE INTERNATIONAL
卷 166, 期 1, 页码 58-67出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.forsciint.2006.03.027
关键词
hair and nails; sedative drugs; benzodiazepines; zopiclone; drug-facilitated sexual assault
Drug screening methods were developed to detect alprazolam, clobazam, clonazepam, diazepam, midazolam, oxazepam, temazepam, triazolam, zopiclone, and selected metabolites in human hair and nail samples employing liquid-liquid extraction and tandem liquid chromatography-mass spectrometry (LC-MS-MS). Hair and nail samples were obtained from patients who had recently discontinued or were currently prescribed one or more of the targeted drugs. Prazepam was used as the internal standard for all compounds. Some components in the hair matrix gave the same transitions as some of the analytes but did not compromise the analyses because their retention times differed from those for the target compounds. The analytical run time was 8-10 min. Results of the hair analysis of a DFSA victim are also presented. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
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