期刊
INTERNATIONAL JOURNAL OF ONCOLOGY
卷 47, 期 1, 页码 91-96出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ijo.2015.2992
关键词
malignant glioma; brain-tumor stem cells; glioma stem-like cells
类别
资金
- Health Sciences Research Institute, Inc., Yokohama
- Japan for Division of Companion Diagnostics
- Department of Pathology of Microbiology, Nihon University School of Medicine
Glioma stem-like cells (GSCs) could have potential for tumorigenesis, treatment resistance, and tumor recurrence (GSC hypothesis). However, the mechanisms underlying such potential has remained elusive and few ultrastructural features of the cells have been reported in detail. We therefore undertook observations of the antigenic characteristics and ultrastructural features of GSCs isolated from human glioblastomas. Tumor spheres formed by variable numbers of cells, exhibiting a variable appearance in both their size and shape, were frequently seen in GSCs expressing the stem cell surface markers CD133 and CD15. Increased cell nucleus atypia, mitochondria, rough endoplasmic reticulum, coated vesicles, and microvilli, were noted in the GSCs. Furthermore, cells at division phases and different phases of the apoptotic process were occasionally observed. These findings could imply that GSCs have certain relations with human neural stem cells (NSCs) but are primitively different from undifferentiated NSCs. The data may provide support for the GSC hypothesis, and also facilitate the establishment of future glioblastoma treatments targeting GSCs.
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