期刊
ANALYTICAL CHEMISTRY
卷 79, 期 4, 页码 1696-1701出版社
AMER CHEMICAL SOC
DOI: 10.1021/ac062223z
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资金
- Engineering and Physical Sciences Research Council [EP/D037662/1] Funding Source: researchfish
- EPSRC [EP/D037662/1] Funding Source: UKRI
We demonstrate the use of spatially offset Raman spectroscopy (SORS) in the identification of counterfeit pharmaceutical tablets and capsules through different types of packaging. The technique offers a substantially higher sensitivity than that available from conventional backscattering Raman spectroscopy. The approach is particularly beneficial in situations where the conventional Raman backscattering method is hampered or fails because of excessive surface Raman or fluorescence signals emanating from the packaging, capsule shell, or tablet coating contaminating the much weaker subsurface Raman signals of the active pharmaceutical ingredients and excipients held in the product. It is demonstrated that such interfering signals can be effectively suppressed by SORS.
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