期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 28, 页码 7198-7202出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402911
关键词
biosynthesis; cyclization; enzyme catalysis; natural products; reaction mechanism
资金
- NIH [GM076324]
- Alexander von Humboldt Foundation
An active-site water molecule coordinated by conserved histidine and asparagine residues seems to serve as the catalytic base in all ent-copalyl diphosphate synthases (CPSs). When these residues are substituted by alanine, the mutant CPSs produce stereochemically novel ent-8-hydroxy-CPP. Given the requisite presence of CPSs in all land plants for gibberellin phytohormone biosynthesis, such plasticity presumably underlies the observed extensive diversification of the resulting labdane-related diterpenoids.
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