期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 25, 页码 6506-6510出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201402620
关键词
C-H activation; cyclization; heterocycles; N-heterocyclic carbene; organocatalysis
资金
- Singapore National Research Foundation (NRF)
- Singapore Economic Development Board (EDB)
- GlaxoSmithKline (GSK)
- Nanyang Technological University (NTU)
- National Research Foundation [NRF-CRP4-2008-02]
Organocatalytic ester activation is developed for a highly selective cascade reaction between saturated esters and amino enones. The reaction involves activation of the b-carbon atom of the ester as a key step. This method allows a single-step access to multicyclic oxoquinoline-type heterocycles with high enantiomeric ratios.
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