期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 53, 期 15, 页码 3993-3995出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201311192
关键词
fluorescent probes; imaging agents; invivo imaging; NAD(P)H; redox chemistry
资金
- JST-CREST
The nicotinamide adenine dinucleotide (NAD) derivatives NADH and NADPH are critical components of cellular energy metabolism and operate as electron carriers. A novel fluorescent ubiquinone-rhodol derivative (UQ-Rh) was developed as a probe for NAD(P)H. By using the artificial promoter [((5)-C5Me5)Ir(phen)(H2O)](2+), intracellular activation and imaging of NAD(P)H were successfully demonstrated. In contrast to bioorthogonal chemistry, this bioparallel chemistry approach involves interactions with native biological processes and could potentially be used to control or investigate cellular systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据