期刊
JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
卷 45, 期 4, 页码 688-698出版社
WILEY
DOI: 10.1002/pola.21741
关键词
atom transfer radical polymerization (ATRP); diblock copolymers; nanoparticles; poly(D,L-lactide) (PLA); poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC)
A poly(D,L-lactide)-bromine macroinitiator was synthesized for use in the preparation of a novel biocompatible polymer. This amphiphilic diblock copolymer consisted of biodegradable poly(D,L-lactide) and 2-methacryloyloxyethyl phosphorylcholine and was formed by atom transfer radical polymerization. Polymeric nanoparticles were prepared by a dialysis process in a select solvent. The shape and structure of the polymeric nanoparticles were determined by H-1 NMR, atomic force microscopy, and xi-potential measurements. The results of cytotoxicity tests showed the good cytocompatibility of the lipid-like diblock copolymer poly(2-methacryloyloxyethyl phosphorylcholine)block-poly(D,L-lactide). (c) 2006 Wiley Periodicals, Inc.
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