期刊
JOURNAL OF IMMUNOLOGY
卷 178, 期 4, 页码 1981-1985出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.178.4.1981
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资金
- MRC [G117/424] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/B/02010] Funding Source: researchfish
- Medical Research Council [G117/424] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BBS/B/02010] Funding Source: Medline
- Medical Research Council [G117/424] Funding Source: Medline
At the immature B cell stage the BCR signals the down-regulation of the RAG genes and Ig L chain (LC) allelic and isotype exclusion. The signaling pathway that regulates these events is poorly characterized. We demonstrate that immature B cells from mice deficient in the PI3K catalytic subunit p110 delta fail to suppress RAG expression and inappropriately recombine K and A LC loci. In addition, in the presence of the autoantigen, clonal deletion and receptor editing still takes place, demonstrating that these processes are independent of p110 delta. These results demonstrate a role for p110 delta in the regulation of RAG gene expression and thereby LC alleliclisotype exclusion. The journal of Immunology, 2007,178:1981-1985.
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