期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 458, 期 2, 页码 136-140出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2006.09.012
关键词
lycopene; lycopenoids; phytoene; phytofluene; carotenoids; tomato; prostate cancer; carotenoid monooxygenase I; carotenoid monooxygenase II; beta-carotene
In vitro lycopene is the most potent antioxidant among carotenoids. While antioxidant function may be relevant to health, we hypothesize that metabolites of lycopene may be bioactive and responsible for the beneficial effects of tomato product consumption. We term these metabolites lycopenoids, which we believe may be produced from carotenoid monooxygenase (CMO) II, paralleling the production of retinoids from beta-carotene by CMO I. We present evidence suggesting that tomato carotenoid metabolites may be responsible for the reduced risk of prostate cancer seen in men consuming high levels of tomato products. Finally, we identify gaps in knowledge in this evolving area of carotenoid research. (c) 2006 Elsevier Inc. All rights reserved.
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