期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 458, 期 2, 页码 141-145出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2006.11.025
关键词
aging; carotene; carotenoids; cryptoxanthin; inflammation; lutein; lycopene; muscle; sarcopenia; zeaxanthin
资金
- Intramural NIH HHS [Z99 AG999999] Funding Source: Medline
- NIA NIH HHS [R01 AG027012, N01-AG-916413, N01-AG-5-0002, N01-AG-821336] Funding Source: Medline
Sarcopenia, or loss of muscle mass and strength, plays a major role in the disablement process in older adults and increases the risk of impaired physical performance, falls, physical disability, frailty, and death. Oxidative stress is a major mechanism implicated in the pathogenesis of sarcopenia; aging muscle shows increased oxidative damage to DNA, protein, and lipids. Carotenoids quench free radicals, reduce damage from reactive oxygen species, and appear to modulate redox-sensitive transcription factors such as NF-kappa B that are involved in the upregulation of IL-6 and other proinflammatory cytokines. Recent epidemiological studies in community-dwelling older adults show that low serum/plasma carotenoids are independently associated with low skeletal muscle strength and the development of walking disability. These observations are consistent with a growing number of studies showing that a diet with high intake of fruits and vegetables is associated with a reduced risk of inflammation, hypertension, diabetes, cardiovascular disease, and mortality. (c) 2007 Published by Elsevier Inc.
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